Due to the expanding interest in the humanized liver mouse model across a wide range of drug development fields, the company now offers services in the following areas:
Specific categories of scientific evaluations performed by KMT Hepatech include:
PK / Tolerability evaluations
Proof of concept: vehicle versus drug treatment
Dose response study
Combination therapy study
Head-to-head comparison of different drugs
In vivo resistance evaluations
Prediction of dosage ranges for clinical trials
Evaluation of preventive therapies
Human-type drug metabolism evaluation
Human lipoprotein metabolism and therapies
Assessment of hepatotoxicity
Our scientists work closely with your scientific team, utilizing a collaborative approach to develop an evaluation strategy that meets your priorities and needs. We will customize studies to answer your most urgent questions related to the evaluation of a potential product and to provide you with the highest possible level of assurance that your lead candidate meets your expectations prior to entering clinical trials.
For each client relationship, a joint Research Steering Committee monitors progress and directs the research agenda. This ensures the client achieves their research objectives according to their timeline and their budget utilizing the KMT Mouse™.
PO 1-3x daily up to 10 ml/kg
SC max volume 1 ml
IM max 0.05 ml 1x daily
IP max up to 15 ml/kg
IV max 0.1 ml
Frequency and duration of dosing regimes assessed per individual study protocol development and are governed by guidelines set by the CCAC and local ACC review.
Recovery blood sampling volume of ~100 µl/animal. Draws can be done weekly. Cardiac blood sampling terminal bleed yields volume range of 300 – 1000 µl based on animal size and condition.
Liver and Organs
Targeted collection is available at the end of study regime as per study protocol development.